Multiple target‐based combination therapy of galantamine, memantine and fisetin for the possible treatment of Alzheimer’s disease

Abstract Dementia is defined by problems associated with memory, communication, problem‐solving, and other thinking abilities that impair a person’s capacity to carry out daily activities. Alzheimer’s disease one of the them in which cognitive functions get declined. Globally, more than 44 million people are diagnosed dementia till 2021. The Pathophysiology degeneration acetylcholine neurons cerebral cortex hippocampus parts brain, enhanced oxidative stress, neuroinflammation, mitochondrial dysfunction. Many clinical preclinical studies have been reported on treatment AD but very limited number drugs found application. Because regeneration complicated process due involvement multiple pathways, combination can work through pathways could prove be effective treating AD. Based prior different mechanisms involved treatment, new hypothesis has proposed galantamine, memantine fisetin anticipated produce better activity as compared current therapies available market for this disease.